The next level of TMS Therapy


Transcranial Magnetic Stimulation is increasingly establishing itself as a new treatment method for strokes, depression and other diseases.

And we make it even better …

Why we exist

Our mission is to develop new personalized brain-stimulation therapies for patients suffering from neuropsychiatric disease such as stroke or depression.

Impact on Neuroscience

We enable studying the transient large-scale dynamics of the human brain with easy-to-program real-time signal processing technology that reads a stream of EEG data and triggers stimulation during pre-defined oscillatory brain-states.

Impact on Medicine

We believe that this technology will unlock the therapeutic potential of non-invasive brain stimulation.

Impact on Healthcare System

TMS, especially personalized TMS therapy, can improve or replace other therapy forms for common diseases, often at a fraction of their costs.

Next-Generation TMS

sync2brain technology is enabling a wide range of basic science, clinical research, and technology partnership.

Clinical Studies

Research Labs


Grants in EUR

About US

sync2brain was founded out of a technology transfer research project at the University of Tübingen with support by a grant from the German ministry of economic affairs in the EXIST Transfer of Research program, with support from the European Social Fund.

Open Source Software

An open source application programming interface (API) is available that allows you to use the bossdevice for your purpose.

Download & Documentation:

Meet our Team, …

Dr. Ramona Samba

Dr. Ramona Samba


Dr. Brigitte Zrenner

Dr. Brigitte Zrenner

Head of Clinical Affairs & Co-Founder

Dr. Christoph Zrenner

Dr. Christoph Zrenner

CTO & Co-Founder

Dr. Gabor Kozak

Dr. Gabor Kozak

Technical Development and Senior Scientist

Umair Hassan

Umair Hassan

Technical Development and Senior Scientist

Niko Mangold

Niko Mangold

Head of Quality Assurance and Regulatory Affairs

TMS in Stroke

TMS therapy is offered at the TMS clinic at the University Neurology Hospital of Tübingen, including clinical trials with sync2brain technology. Please see for details and to schedule an appointment for an evaluation. An application to the insurance company for reimbursement of the therapy cost is recommended.

Coverage in Media

The Technology

The bossdevice plugs into a compatible EEG amplifier on the input side and a brain stimulation device on the output side. It reads a real-time biosignal data stream and generates trigger signal when a pre-defined EEG-state is detected. The bossdevice is programmable from Matlab and enables complex experiments to be fully automated.

N. B.:  A license of Matlab Version 2017b is required and usually available at academic institution as part of a site-license agreement with Mathworks.

Compatible EEG amplifiers

Bittium NeurOne with Real-time DigitalOut, Brain Products actiCHamp with TurboLink

Channels and sample rate
up to 128 EEG channels, 8 AUX channels, 5 kHz sample rate
Spatial filtering

2 simultaneous signals, fully flexible (e.g. left + right, frontal + temporal)

Oscillatory states
Phase and amplitude (theta, alpha, and beta)
4x BNC (TTL) trigger, 1 marker output (LPT)
CE mark – not medical

For research use only, in studies with healthy participants only *

* Please contact sync2brain if you intend to use the device with patients

Let’s get in contact

Thanks to our Supporters